Hyperhidrosis is a condition that causes excessive sweating beyond the body's natural need for temperature regulation. While it is not life-threatening, it can significantly affect quality of life and daily functioning. Fortunately, several treatment options are available, ranging from over-the-counter products to surgical procedures.

Finding the right treatment may require some trial and error, and often depends on which part of the body is affected and how severe the sweating is. Many people benefit from a combination of approaches to manage their symptoms effectively.

Medications

Various medications—both topical and oral—can help reduce excessive sweating.

anticholinergics
These oral medications work by blocking the chemical signals that stimulate sweat production. Common prescriptions include benztropine, glycopyrrolate, oxybutynin, and propantheline. While originally intended for other conditions, they are often prescribed “off-label” for hyperhidrosis.

antiperspirants
Over-the-counter and prescription antiperspirants are among the most common treatments. They work by temporarily plugging sweat ducts and are typically applied to the underarms, hands, feet, or hairline. Extra-strength products like Certain Dri (OTC) or Drysol (prescription) are commonly recommended. For best results, apply to dry skin at night and wash off in the morning.

beta-blockers and benzodiazepines
These medications help reduce sweat triggered by anxiety or high-stress situations, such as public speaking or social interactions.

topical wipes
Qbrexza (glycopyrronium) is a prescription cloth wipe approved for use on underarms. It works by delivering an anticholinergic agent directly to the skin to block sweat gland activation.

note on side effects
Some high-strength antiperspirants may cause itching, burning, or irritation. Always follow application instructions carefully and consult a dermatologist if irritation occurs.

Surgeries And Procedures

If medications and topical treatments are not effective, healthcare providers may recommend procedures designed to reduce or eliminate sweat gland activity.

botox injections
Botox can block nerve signals that trigger sweating when injected into specific areas like the underarms, hands, or feet. The effects typically last a few months, and many people combine Botox with topical treatments for better results.

endoscopic thoracic sympathectomy (ETS)
ETS is a surgical procedure where the nerves that stimulate sweat glands are cut or destroyed. This is often considered a last resort due to its permanence and the possibility of compensatory sweating (sweating in other areas of the body).

fractional microneedle radiofrequency
This procedure uses tiny needles to deliver radiofrequency energy into the sweat glands. It usually requires multiple sessions and is performed by a specialist.

iontophoresis
A non-invasive treatment that involves immersing hands or feet in water while a mild electrical current passes through. It temporarily shuts down sweat glands in the treated area. At-home iontophoresis devices are available for personal use.

laser therapy
Laser energy targets and destroys sweat glands, particularly in the underarms. Treatments typically take less than an hour, though long-term effectiveness can vary.

miraDry
miraDry is a non-invasive procedure that uses microwave technology to destroy underarm sweat glands. Approved by the FDA, this treatment offers long-lasting results for many people.

surgical removal
In some cases, providers may physically remove sweat glands through excision (cutting), curettage (scraping), or liposuction (suctioning). These methods are permanent and typically used only in severe cases.

Living With And Managing Hyperhidrosis

Although hyperhidrosis is not dangerous, it can cause significant emotional and social challenges. Many people feel self-conscious, frustrated, or anxious because of their symptoms.

tips for managing daily life with hyperhidrosis:

  • keep a sweat journal: Tracking your sweating patterns can help identify triggers such as spicy foods, caffeine, or alcohol.

  • see a dermatologist: A specialist can help you determine the most effective treatment based on your specific symptoms and lifestyle.

  • care for your feet: Change socks daily, wear breathable shoes, and avoid wearing the same footwear two days in a row to prevent fungal infections.

  • use antiperspirants, not just deodorants: Antiperspirants block sweat, while deodorants only mask odor. Apply at night for better absorption and results.

With the right support and treatment plan, managing hyperhidrosis is entirely possible—and many people achieve a better quality of life.

A Quick Review

Hyperhidrosis causes excessive sweating that goes beyond the body’s need to regulate temperature. While mild cases may respond to antiperspirants or lifestyle changes, moderate to severe cases often require medical intervention.

Treatments include medications, Botox, microwave and laser therapy, or even surgical options in extreme cases. The best approach depends on the location and severity of the sweating and how you’ve responded to previous treatments. If sweating disrupts your daily life, talking to a healthcare provider can help you find a personalized solution.