Many cancers do not cause noticeable symptoms in their early stages, and this is often true for lymphoma—especially the slow-growing, low-grade types.

However, even low-grade lymphoma can eventually cause issues. It may progress into a more aggressive form over time, at which point symptoms are much more likely to appear or become troublesome.

Common Signs of Lymphoma

Lymphoma symptoms can vary significantly between individuals. Many of these signs are vague and may be linked to other, less serious conditions. Still, it’s important to stay aware of them and consult a healthcare provider if you notice anything unusual.

Swollen lymph nodes

lymphoma affects white blood cells in the lymphatic system

Lymphocytes, a type of white blood cell, are primarily found in lymph nodes, including those in your neck, armpits, and groin. The spleen also houses many lymphocytes.

lymph nodes enlarge without infection

When fighting an infection, lymph nodes often swell and become tender. But in lymphoma, nodes swell due to a buildup of cancerous lymphocytes and usually aren’t painful. Some people may feel a dull ache or pressure in the area.

Fever or chills

immune response activation

Fever is a common response when the immune system is triggered, whether by an infection or cancer cells like those in lymphoma. If you're experiencing unexplained fevers, it may warrant further medical evaluation.

Night sweats

intense sweating during sleep

Waking up drenched in sweat may occur due to menopause or autoimmune diseases, but it’s also common in lymphoma. The exact reason isn't fully understood, but it's thought to be linked to chemical signals released by cancer cells. Night sweats may also be related to sudden nighttime fevers or trouble regulating body temperature.

Loss of appetite

feeling full quickly or persistent nausea

Lymphoma may affect abdominal lymph nodes or lymphatic tissues in organs like the liver or spleen. This can lead to symptoms such as bloating, nausea, and abdominal pain.

pressure from enlarged spleen or liver

An enlarged spleen can press against the stomach, making you feel full after eating small amounts. Lymphoma in the liver may also cause fluid buildup, leading to bloating and discomfort.

Persistent fatigue

linked to anemia

Fatigue is common and non-specific, but when related to lymphoma, it often stems from anemia. Because cancerous lymphocytes overcrowd the bone marrow, the production of red blood cells decreases, reducing oxygen delivery throughout the body.

Easy bruising or bleeding

low platelet counts cause clotting issues

If you’re bruising more easily than usual, having frequent nosebleeds, or experiencing heavy menstrual bleeding, it may be due to a drop in platelets. Lymphoma can impair the bone marrow’s ability to produce enough platelets, which are essential for blood clotting.

Coughing, chest pressure, or shortness of breath

swollen nodes in the chest cavity

Lymphoma can begin in the thymus gland or nearby lymph nodes in the chest. When these enlarge, they may press on the trachea or lungs, leading to dry cough, chest discomfort, or breathing difficulties.

common symptoms include

  • Dry or persistent cough

  • Loud breathing

  • Chest pain or pressure

  • Shortness of breath

  • Worsening symptoms when lying down

These signs are frequently associated with Hodgkin lymphoma but can also appear in other types.

Unexplained weight loss

significant drop without lifestyle changes

Losing more than 10% of your body weight in six months without a change in diet or exercise habits can signal an underlying issue. In aggressive forms of lymphoma, the body uses more energy to fuel rapid cancer cell growth and immune response.

Itchy skin

widespread or localized irritation

While dry skin or allergies are typical culprits for itching, persistent or severe itch—especially in the hands, legs, or feet—can indicate lymphoma. Some patients experience a burning sensation or visible rash, though not always.

linked to immune system activity

Cytokines released by lymphoma cells can irritate nerve endings in the skin, leading to chronic itchiness, which may affect localized skin patches or even the entire body.

When to Contact a Healthcare Provider

If you experience any of these symptoms or something simply feels off in your body, it's important to seek medical advice. While many of these signs can be due to non-cancerous conditions, early detection of lymphoma can lead to more treatment options and better outcomes.

tips for your doctor’s visit

  • Keep a symptom journal noting onset, frequency, and severity

  • Track what worsens or improves your symptoms

  • Be honest about your concerns, even if you fear it may be lymphoma

  • Share any family history of cancer

  • Don’t hesitate to ask for clarification or write down medical advice

A Quick Recap

Lymphoma refers to a range of cancers that begin in the lymphatic system. The two primary types are Hodgkin lymphoma and non-Hodgkin lymphoma.

Experiencing one or more symptoms listed above doesn’t automatically mean you have cancer. However, consulting with a medical professional ensures early evaluation and, if necessary, timely treatment.