Yohimbe is an evergreen tree native to Africa. Traditionally, its bark has been used as a remedy for ailments ranging from coughs to heart problems, as well as an aphrodisiac and anesthetic. In modern times, yohimbe and its active compound yohimbine are often marketed in the West as supplements for sexual health, particularly for erectile dysfunction (ED).

Potential Benefits

Support for Erectile Dysfunction

Some research suggests yohimbe may help improve erections and enhance sexual satisfaction. A few studies indicate it could be more effective when combined with other supplements, like L-arginine, which improve blood flow to the penis. However, experts caution against using yohimbe as a standard treatment because of safety concerns and inconsistent results.

Athletic Performance

Yohimbe has stimulant properties that may increase energy and reduce exercise-related fatigue. Some small studies have reported enhanced endurance and blood flow, but strong evidence is still lacking. Because of its stimulating effects, yohimbe can also raise heart rate and blood pressure, making medical supervision essential.

How to Use Yohimbe

Yohimbe is available in capsules, powders, or liquid extracts made from the bark. In the U.S., a prescription form known as yohimbine hydrochloride (Aphrodyne) is sometimes prescribed for ED.

There is no universally agreed safe dosage. Some studies suggest 5–10 mg three times daily, while others refer to therapeutic levels measured in the bloodstream. Over time, tolerance can develop, which reduces effectiveness.

Safety Concerns

Yohimbe is linked to a high risk of side effects, including heart palpitations, high blood pressure, chest pain, anxiety, and digestive issues. Severe outcomes such as seizures, heart attack, or even death have been reported with overdoses.

Because of these dangers, several countries have banned or restricted yohimbe as a supplement. Pregnant or breastfeeding individuals, children, and those with heart conditions should avoid it completely.

Drug Interactions

Yohimbe may interfere with medications, especially:

• Antidepressants (MAO inhibitors): such as phenelzine or tranylcypromine

• Blood pressure and diuretic medications: because yohimbe can release norepinephrine, worsening blood pressure control

Always consult a healthcare provider before combining yohimbe with any prescription drug.

Quality and Regulation

Herbal supplements are not regulated by the U.S. Food and Drug Administration (FDA). Some yohimbe products may not accurately list their ingredients or the amount of yohimbine they contain. Independent testing by groups like ConsumerLab, NSF International, or USP can improve safety, but availability is limited since yohimbe is restricted in many countries.

Side Effects

Common side effects include:

• Nausea, dizziness, sweating

• Insomnia, anxiety, restlessness

• Stomach upset, high blood pressure, chest pain

Serious complications from overdose may include:

• Rapid or irregular heartbeat

• Confusion, tremors, or seizures

• Heart attack or paralysis

• Coma and death in extreme cases

A Quick Review

Yohimbe has a long history of use as a natural aphrodisiac and stimulant, and some studies suggest it may help with erectile dysfunction and athletic performance. However, safety concerns, inconsistent results, and the lack of established safe dosages make it a risky option. Safer, evidence-based treatments for ED—such as PDE-5 inhibitors, lifestyle changes, and counseling—are generally recommended first.