Nitric oxide (NO) is a gas that your body naturally produces, playing an essential role in blood flow, circulation, and overall cardiovascular health. It helps relax the blood vessels, which lowers blood pressure and allows nutrients and oxygen to reach muscles and organs more efficiently.

Most nitric oxide supplements don’t actually contain NO but include amino acids like L-arginine and L-citrulline, which support NO production. Others include nitrates from beetroot, which convert into NO through different pathways. These supplements are commonly used by athletes, people with high blood pressure, and individuals seeking to improve energy and heart function.

To help you choose the right supplement, we consulted with registered dietitians and analyzed dozens of products based on ingredients, certifications, user feedback, and third-party testing.

Our Top Picks for Nitric Oxide–Boosting Supplements

  • Best Overall: Nitric Boost

  • Best Budget: Double Wood Supplements Nitric Oxide Booster

  • Best for Muscle Growth: CON-CRET Creatine HCl + Nitric Oxide

  • Best for Heart Health: Pure Encapsulations Nitric Oxide Ultra

  • Best Vegan: Jarrow Formulas Arginine-Citrulline Sustain

Best Overall: Nitric Boost

  • Form: Capsule

  • NO Ingredients: L-arginine, L-citrulline, beetroot extract, vitamins C, D3, B12, magnesium, zinc

  • Pros:

    • Well-rounded formula supporting energy, heart health, and endurance

    • Includes antioxidant vitamins

    • Easy-to-swallow capsules

    • CGMP-certified manufacturing

    • 180-day money-back guarantee

  • Cons:

    • Only available online

    • Not NSF Certified for Sport

Why We Like It: Nitric Boost combines clinically backed ingredients to naturally increase nitric oxide through multiple pathways. It’s suitable for daily use, free from stimulants, and designed to improve both blood flow and vitality. Ideal for individuals looking to support cardiovascular health, energy levels, and circulation.

Best Budget: Double Wood Supplements Nitric Oxide Booster

  • Form: Capsule

  • NO Ingredients: Nitrosigine, L-citrulline, arginine AKG, arginine HCl

  • Pros:

    • Low price per serving

    • Vegan-friendly and CGMP-certified

    • Transparent third-party testing

  • Cons:

    • Requires 3 capsules per dose

    • Lower NO ingredient dosage

Why We Like It: For budget-conscious consumers, it delivers solid ingredients in a cost-effective format backed by quality assurance.

Best for Muscle Growth: CON-CRET Creatine HCl + Nitric Oxide

  • Form: Powder

  • NO Ingredients: 750 mg citrulline HCl, 2,000 mg beetroot powder

  • Other: 750 mg creatine HCl

  • Pros:

    • Includes creatine for muscle performance

    • No added sugars or colors

  • Cons:

    • Not third-party tested

    • Multiple servings required

Why We Like It: Combines nitric oxide support with creatine for muscle growth and recovery, ideal for strength athletes.

Best for Heart Health: Pure Encapsulations Nitric Oxide Ultra

  • Form: Capsule

  • NO Ingredients: 1,000 mg L-citrulline

  • Other: Cranberry and grape seed extracts

  • Pros:

    • Hypoallergenic and allergen-free

    • Backed by antioxidant support

    • Third-party tested

  • Cons:

    • Low L-citrulline dose

    • Results may vary

Why We Like It: Designed for people with cardiovascular concerns, this option adds powerful antioxidants for added vessel support.

Best Vegan: Jarrow Formulas Arginine-Citrulline Sustain

  • Form: Tablet

  • NO Ingredients: 500 mg L-arginine, 500 mg L-citrulline

  • Pros:

    • Free from allergens

    • Certified vegan and third-party tested

  • Cons:

    • Tablets may crumble

    • Lower dose than others

Why We Like It: A solid, allergen-friendly option for vegans looking for basic NO support.

Final Thoughts

Each of these nitric oxide boosters offers unique benefits, whether you're looking for improved workout performance, blood pressure support, or heart health. Nitric Boost stands out for its complete formula, ease of use, and versatility, making it the top overall pick for 2025.

Always speak with a healthcare provider before starting any supplement, especially if you have medical conditions or are on medication.