Dietitians’ Picks: The Best Weight Loss Supplements to Help Shed Fat in 2025

Millions of Americans use weight loss supplements, fueling a $2 billion industry. With over 40% of adults facing weight challenges, these products remain popular. While not a quick fix, supplements can support healthy habits like better diet and exercise—some boost metabolism directly, others help control appetite. To guide you, we asked three registered dietitians to recommend their top supplements for 2025 and share tips for safe, effective use.

Our Top Weight Loss Supplement Picks for 2025

• Best for Women: Orgain Organic Plant-Based Protein with 50 Superfoods

• Best Mitochondrial Support for Weight Loss: Mitolyn

• Best Collagen Supplement: Vital Proteins Collagen Peptides

• Best Creatine: Thorne Creatine

• Best Omega-3: Nordic Naturals Ultimate Omega

• Best for Metabolism: Pure Encapsulations Green Tea Extract

When to Talk to Your Doctor

Before beginning any weight loss supplement, consult a healthcare provider, especially if you take medications or have chronic health issues. Some supplements, particularly those with stimulants like caffeine, may cause side effects involving heart rate or blood pressure. Additionally, dietary supplements are not regulated as strictly as prescription medications, so opt for products that have been third-party tested.

Supplement Spotlights

1. Orgain Organic Plant-Based Protein With 50 Superfoods – Best for Women

Pros:

• Contains protein and fiber.

• Superfood blend provides nutrients and antioxidants.

• 160 calories per serving.

• Plant-based.

Cons:

• May be overly sweet.

• Can clump while mixing.

2. Mitolyn - Best Mitochondria-Boosting Weight Loss Supplement

Pros:

• Supports Mitochondrial Function: Mitolyn is formulated to enhance mitochondrial activity, which may help boost metabolism and energy production. 
• Natural Ingredients: Contains a proprietary blend of six natural ingredients, including Maqui Berry, Rhodiola, Haematococcus (Astaxanthin), Amla, Theobroma Cacao, and
• Schisandra, known for their antioxidant properties. 
• Stimulant-Free: Unlike some weight loss supplements, Mitolyn does not contain caffeine or other stimulants, reducing the risk of jitteriness or sleep disturbances. 
• Manufactured in the USA: Produced in FDA-approved and GMP-certified facilities, ensuring quality and safety standards. 
• Money-Back Guarantee: Offers a 90-day satisfaction guarantee, allowing customers to try the product risk-free. 

Cons:

• ​​​​​​Requires Consistent Use: Optimal results may require consistent use over several months, which may not appeal to those seeking quick fixes. 
• Limited Availability: Primarily available through the official website, which may be inconvenient for some customers.
• Potential Digestive Sensitivity: Some users may experience mild digestive discomfort when starting the supplement, though such effects are generally temporary.
• Not Suitable for Everyone: Individuals with specific medical conditions or those taking certain medications should consult a healthcare provider before use.

3. Vital Proteins Collagen Peptides – Best Collagen

Pros:

• Supports skin and joint health.

• May help with fullness and muscle mass.

• NSF Certified for Sport.

• Available in several flavors.

Cons:

• No scoop included.

• Not vegan-friendly.

4. Thorne Creatine – Best Creatine

Pros:

• Third-party tested and NSF Certified for Sport.

• May support muscle mass and recovery.

• Improves brain energy.

• Mixes easily into any beverage.

Cons:

• May have a bitter taste.

• Pricier than other creatine supplements.

5. Nordic Naturals Ultimate Omega – Best Omega-3

Pros:

• Contains 1,280 milligrams of omega-3.

• May help reduce chronic inflammation.

• Doesn’t cause fishy burps.

• Third-party tested and Friend of the Sea certified.

Cons:

• Not vegan-friendly.

• May interfere with some medications.

6. Pure Encapsulations Green Tea Extract – Best for Metabolism

Pros:

• May boost metabolic rate.

• Third-party tested.

• Caffeine-free.

• Concentrated source of green tea compounds.

Cons:

• May affect liver health.

• Pricey if you take multiple capsules daily.

Comparison Table

How to Choose Safe and Effective Weight Loss Supplements

When shopping for supplements, keep in mind:

• Ingredients: Understand what each ingredient does and how it supports weight loss.

• Testing: Look for third-party certifications like NSF or Informed Choice.

• Budget: Don’t overspend—supplements are optional, not essential.

• Form: Choose a format (capsule, powder, liquid) that fits your lifestyle.

Types of Weight Loss Supplements

• Muscle Builders: Protein powders, creatine

• Appetite Suppressants: Fiber, probiotics, prebiotics

• Fat Burners: Caffeine, green tea extract, MCT oil

Are These Supplements Safe?

Most are safe when used as directed, but consult your doctor, especially if you take medications. Look for:

• Ingredient transparency

• Reasonable dosages

• Third-party testing

• Absence of banned or harmful substances

Avoid exceeding doses and watch your total caffeine intake to reduce the risk of side effects.

Lifestyle Still Matters Most

Diet

Stick to sustainable, enjoyable eating habits. Avoid extreme calorie-cutting diets.

Exercise

Aim for 150+ minutes of activity weekly. Resistance training is especially helpful.

Stress Management

Chronic stress can undermine weight loss. Practice mindfulness, improve sleep, and consider therapy for emotional support.